We study membrane protein science at single-molecule resolution, hopefully contributing to pertinent areas of pharmacy and medicine. Proteins classified as membrane proteins are the key targets of commercial drugs (~60% of drugs), and thus better understanding of their hidden chemistry and physics cannot be more emphasized to develop effective strategies of therapeutic intervention. However, the progress is relatively slow due to the technical challenges in handling the recalcitrant membrane proteins. The vision of our laboratory is not only to understand their fundamental bio-physico-chemical principles such as misfolding disease mechanisms at single-molecule level, but also to develop new methods tackling the notorious.
News Updates
2024
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03 | Welcome, Dr. Kim! We are excited to have you as our lab's Post-Doc.
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02 | Dr. Min's invited review paper has been published in Biochemical Society Transactions, titled "Folding speeds of helical membrane proteins" (Link to the paper). Congratulations!
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02 | Seoyoon has received the best publication award for her outstanding work on "the speed limit of membrane protein folding" in the Department of Chemistry. Congrats!
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01 | Eojin has received an outstanding poster award for his work on "protein oxidative damage" at the 4th Biological Physics Symposium of the Korean Physical Society. Congrats!
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01 | Our invited book chapters have been published in a volume of Methods in Enzymology, titled "Magnetic Tweezers for the Study of Protein Structure and Function". The book chapters are authored by Seoyoon, Daehyo, and Dr. Min, providing step-by-step procedures for our single-molecule tweezer approach to membrane protein structural dynamics (Link to the first chapter and Link to the second chapter). Congratulations!
2023
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11 | Eojin has received an award for his outstanding presentation on "protein aging" at the fall meeting of the Korean Physical Society. Congrats!
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11 | Our invited preview paper has been published in Structure as a part of the 30th anniversary special issue. Eojin and Dr. Min wrote this preview, putting recent single-molecule findings on a protein folding chaperone in perspective (Link to the paper). Congrats!
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06 | Our invited review paper has been published in Journal of Molecular Biology as a part of a special issue titled "Changing Shape of Molecules and Changing Landscape of Molecular Biology". Bhashini and Dr. Min wrote an extensive review on single-molecule force spectroscopy of membrane protein folding (Link to the paper). Congratulations!
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05 | The first research paper from our group has been published in eLife. In this work, Seoyoon and Daehyo, with help of Bhashini, developed a robust molecular tweezer method and, for the first time, characterized the "speed limit" of membrane protein folding (Link to the paper). Congratulations!
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02 | Welcome Jeonghyun, another new color to the lab.
2022
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09 | Eojin continues his undergraduate works as a PhD student.
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02 | Welcome Poornima, our new addition to the group as a PhD student.
2021
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04 | Welcome, Bhashini! We are excited to have you as a PhD student.
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03 | Daehyo has just started a PhD program to further advance his undergraduate research.
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02 | Victor has joined our group as a PhD student. Welcome!
2020
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07 | Dr. Min has received additional funding for "The First Innovation Laboratory" among the NRF grant recipients.
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02 | Dr. Min has received the Outstanding Young Researcher grant from the NRF. Yay!
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01 | Razzak and Seoyoon have joined as the lab's first Post-Doc and PhD student. Welcome!
2019
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10 | The lab officially opens in UNIST.